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The regular suspension demonstrated similar effects on the exposure profile of DCU nanosuspension; however, a much reduced absorption rate (δc/δt) and lower exposure was observed (Figure 5).
The simulation results of the latent exposure profile under the different exposure conditions for photoresist AZ4562 have been given with the enhanced exposure model.
It makes possible to determine each subject's exposure profile expressed as AUC of PCBs serum concentration with a minimum model parameters.
A time-dependent increase in Hg accumulation was observed in the continuous exposure, while the intermittent treatment showed step-wise changes in Hg concentrations with the exposure profile, especially in the gills.
For treatment of nocturnal hypoglycemia, however, the target exposure profile is a constant serum concentration over the first 8 10 hours followed by rapid clearance, as described above.
Through application of the XTEN technology, we report the construction of a glucagon fusion protein with an extended exposure profile (Gcg-XTEN).
Construct 1, comprising 288 amino acids of XTEN sequence, demonstrated the longest exposure profile with a terminal half-life of approximately 9 hrs.
Thus, a critical feature of the final molecule is a flat exposure profile that maintains an efficacious dose while minimizing effects on baseline glucose levels.
This analysis was also preceded by evaluation of heterogeneity between the study population and the exposure profile group (interaction term: exposure profile group × study population).
Season might have affected the exposure profile for each woman through other mechanisms, such as inversion.
The cortisol exposure profile of DR-HC was different from that of thrice-daily hydrocortisone.
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