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As a result, they failed to identify changes in reproductive functions that manifest during subsequent pregnancies, leading to an incomplete evaluation of the effects of BPA exposure on fertility.
Regardless, there was no effect of DcHP exposure on fertility or pregnancy in this study and pup viability, development and reflexes were also unaffected even in the pups of animals exposed in utero and throughout their lifespan (Hoshino et al., 2005).
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We currently plan to use the tool to assess the effect of workplace exposures on fertility and pregnancy outcomes amongst laboratory workers and domestic workers in South Africa.
We conclude that detailed prospective studies allowing inferences on day-specific probabilities of conception should be considered as the gold standard for studying the effects of environmental exposures on fertility.
The effect of FA exposure on paternal fertility has only been studied to a limited extent.
The Ethics Committee of the Faculty of Health Sciences, University of Pretoria (reference 43/2003), and the Limpopo Provincial Government Department of Health and Social Development approved the research protocol (11 July 2002) for a study to assess the effect of DDT exposure on male fertility and general health parameters.
Future large-scale studies should incorporate different markers and different seasons to generate a more accurate and full assessment of the adverse effects of PAH exposure on male fertility.
The present study is part of a large collaborative research project, INUENDO, funded by the European Union Commission with the overall aim to estimate the impact of POP exposure on human fertility.
Epidemiologic studies assessing the effects of human exposure to PCBs on fertility and reproduction have yielded various results: some indicate a negative effect of PCBs on fertility, whereas others report no association (Axmon et al. 2001, 2002; Dallinga et al. 2002; Rozati et al. 2002; Yu et al. 2000).
Longer follow-up is needed to assess the effect of latency on risk of ovarian cancer after exposure to fertility drugs.
Although there has been growing concern about the effects of environmental exposures on human fertility, standard epidemiologic study designs may not collect sufficient data to identify subtle effects while properly adjusting for confounding.
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