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In this manner, positively charged molecules are able to modulate CK2 activity to promote the exposure of the active enzyme site.
Addition of isolated pUbl was shown to increase the activity of Parkin (Kazlauskaite et al, 2014b), and Ubl phosphorylation leads to exposure of the active site cysteine while the addition of pUb did not (Ordureau et al, 2014).
This unique configuration leads to a high exposure of the active edge sites and increases charges separation and transfer rate.
Furthermore, oral administration of 15b generated high and sustained systemic exposure of the active parent 15a in rats and dogs.
The process flow further avoids the exposure of the active graphene layers with polymers during plasma processing, reducing the possibility of polymer residues.
Although the wall thickness was <5 nm, no obvious shrinkage and collapse were observed after graphitization, thereby maximizing the exposure of the active sites.
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This indicates a dose-proportional increase in rate of exposure and a slight deviation from dose proportionality in extent of exposure to the active metabolite.
This may reflect the fact that the variant alleles are linked to decreased conversion of tegafur, the active component of S-1, to 5-FU; this might have resulted in reduced exposure to the active metabolite of 5-FU.
These data should be interpreted within the context of the substantially longer exposure to the active drug compared with placebo (122 versus 41 weeks).
The planar configuration of PPy benefits the electron transfer and the exposure of the Co N active sites for the catalysis of ORR.
Furthermore, for researching the relationship of structural changes of MoS2 supported on Co PBA nanocubes and HER catalytic performance, we use the Raman spectroscopy to monitor nanostructured MoS2 which can promote the exposure of the most active sites.
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