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Genital herpes can facilitate HIV-1 acquisition by disrupting the epithelial barrier, thereby increasing exposure of target cells to virus [2], [17] [18].
Exposure of target cells (e.g., stem cells) to ultimate DNA-reactive and mutagenic species, with or without metabolism.
They may also better reflect exposure of target tissues to polyphenols than intake measurements, which do not take into account interindividual variations in bioavailability.
Rather than simply banning substances (see further), restricting the use of products under certain conditions may be an efficient controlling mechanism to limit the exposure of target populations or to limit general exposure.
On the other hand, exposure of target cells to an environmental agent may produce a more direct effect on the epigenome if the effect is mediated by DNA damage.
At this temperature, many bio-molecules will be denatured and solubilised, allowing for lipids and protein complexes to disassociate, hence allowing for exposure of target nucleic acids to the detection chemistry reactants (e.g. primers, probes, enzymes).
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In this work we provide evidence that the heritability of small RNA-induced transgene epialleles depends on the exposure of targets to RNA signals.
In order to investigate the toxic potency of this chemical, three exposure regimes were carried out: chronic exposure of groups of individuals, a new protocol "in tubo" designed for sub-acute exposures of individuals, and acute exposures of target cells.
For all medical exposure of patients for radiotherapeutic purposes, exposures of target volumes shall be individually planned and their delivery appropriately verified taking into account that doses to non-target volumes and tissues shall be as low as reasonably achievable and consistent with the intended radiotherapeutic purpose of the exposure.
There are exposures of target cells to virus that fail to initiate an infection, and there is spread of virus from the initially infected cell(s) that fails to become a systemic infection, collectively adding a bias to the distribution of polymorphisms in the transmitted/founder virus population.
Furthermore, the EURATOM Council Directive 97/43 stipulated that in medical exposures for radiotherapeutic purposes, including nuclear medicine, "exposures of target volumes shall be individually planned".
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