Sentence examples for exposure of mutations from inspiring English sources

That led us to speculate that the solvent exposure of mutations may be indeed an important determinant of their propensity to misfold and to lose the catalytic activity.

Genomic imprinting can affect evolution though selective exposure of mutations in a functionally hemizygous state and has further been suggested to aid a greater variability in quantitative traits that could benefit species in changing environments [ 33].

ChrX's mode of inheritance entails different phenotypic consequences of X-linked polymorphisms, including the exposure of recessive mutations in hemizygous males, a higher chance of dominant mutations affecting females, and more complex mutation models [ 14, 15].

Finally, the regime of frequent selfing was likely violated or even abandoned, thus preventing the exposure of deleterious mutations in the haploid phase.

The more a mitochondrial gene persists in an impaired state (i.e., the complementary strand is displaced), the longer the time of exposure to mutation (e.g., spontaneous cytosine deamination and conversion in uracil).

The risk of breast cancer after radiation exposure among carriers of mutations in the BRCA1 and BRCA2 genes also is unclear.

The low variant frequency observed on the X chromosome of the sequenced animal also suggests that cattle selection often favours a lower mutation rate on the X chromosome compared with on the autosomes because of the exposure of deleterious recessive mutations on hemizygous chromosomes [ 73, 74].

When examining associations with p53 mutation status, participants were cases and controls with complete information regarding the exposure of interest and mutation status.

It has been recognized that one evolutionary cost of this mechanism is the potential accumulation and occasional exposure of a number of mutations which would very often be harmful rather than advantageous [e.g. [ 37, 66, 88]].

In melanoma, the relationship between sun exposure and the origin of mutations in either the N- ras oncogene or the p53 tumour-suppressor gene is not as clear as in other types of skin cancer.

Physical characteristics or environmental exposures of the mutation carriers could also modify their risks of developing CRC (Jenkins et al, 2007).