Three schedules were used to study the effect of sequential and simultaneous exposure of combinations of sapacitabine with other anticancer agents.
The effects of sequential and simultaneous exposure of combinations of pralatrexate with oxaliplatin, cisplatin, 5-FU, 5′-DFUR, SN38, paclitaxel, gemcitabine, erlotinib or lapatinib were evaluated in DU145 cells (Table 2).
The increased use of pesticides has caused concern over the possible direct association of exposure to combinations of these compounds with bee health problems.
Whereas <25% of cultured thoracic cancer cells treated with either VA (1.0 or 5.0 m M) or UCN-01 (500 n M) underwent apoptosis, 60 85% of these cells were TUNEL-positive 48 h after the onset of exposure to combinations of VA+UCN-01.
Her research involves applying statistical models, biomonitoring techniques, and environmental measurements to provide comprehensive and quantitative assessments of exposure to combinations of traditional and emerging environmental contaminants.
Accordingly, the greater debt exposure of the combination plus the difficulty of divesting assets have increased the risks to shareholder value to an unacceptable level," he said.
In contrast, sequential exposure of either combination in either order demonstrated at least an additive response (CI⩽1).
Assessment of risk from exposure to combinations of chemicals requires the knowledge of the underlying mechanism(s).
The Agency for Toxic Substances and Disease Registry (ATSDR), in collaboration with the Dutch Organization for Applied Scientific Research TNOO) Nutrition and Food Research Institute, is conducting studies to evaluate the role of chemical interactions in the expression of toxicity from low-level exposure to combinations of chemicals.
A major concern is how exposure to combinations of low levels of pesticides, especially herbicides, could affect public health.
