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Exposure of cases to risk factors may change because of disease status.
Standard descriptive statistics will be used to describe characteristics and pesticide exposure of cases, controls and mothers/relatives.
The baseline characteristics (age, gender, smoking status, and cumulative asbestos exposure) of cases and controls are presented in Table 1.
Exposure of cases to risk factors may change due to disease status, but most were newly diagnosed within 3 6 months.
In a sensitivity analysis we employed a bi-directional case-crossover referent selection scheme [ 25, 26] and evaluated exposure of cases 7 and 14 days before and after the onset of TIA.
We employed a case crossover design to compare exposure of cases just before a health event ("index") with their exposure sampled from some separate "referent" time period(s) (Levy et al. 2001; Lin et al. 2003; Neas et al. 1999).
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Sampling continued through the course of the outbreak initially concentrated in the documented areas of exposure of case-patients.
The exposure of case subjects and control subjects to different drugs (proportion of patients exposed, time of exposure, and mean daily dose [MDD], units per kilogram per day) for each compound) was compared using χ and Mann-Whitney tests whenever appropriate.
That means that data on possible intrahospital exposures of cases were collected from onset of pneumonia to onset of ALI, whereas in controls, data were tabulated for the same number of hours subsequent to the onset of pneumonia.
Spearman's correlations between estimated exposures of cases in the nine months before and nine months after birth (based on birth address) were 0.95, 0.96, and 0.94 for distance, total power output, and modelled power density, respectively.
Clinicians and pathologists were blind to the exposure status of cases and controls.
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