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These systems consist of a smoking machine (i.e. Borgwaldt RM20S smoking machine [10], Burghart MSB-01 Mimic Smoker [11],[12], and Vitrocell VC 10 smoking robot [13],[14]) and cell culture exposure chambers (i.e. Curbridge Engineering/British American Tobacco [14], Cultex® exposure module, Cultex® radial flow system [6],[15], and Vitrocell® modules [16]).
The collimated neutron beam in the designed system could be useful in a transportable exposure module for neutron radiography application.
It consists of a smoking machine, a dilution device for the smoke, analytical devices for online monitoring and a specially adapted exposure module based on the Cultex2 cell cultivation system that is equipped with a gas-exposure top.
The instability in the distribution of different atmospheres to the cells caused us to create a new exposure module, characterized by a stable and reproducible radial guidance of the aerosol to the cells.
On the fifth day, they participate in either a career exposure module learning from guest speakers and going on site visits with architecture firms, or in a career counseling module in which they are mentored and work on preparing for interviews and presentations, creating resumes and design portfolios, and prepare for the college application process and financial aid and scholarships.
Figure 2 The Vitrocell mammalian exposure module (6/4 CF Stainless).
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Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a hyper-Graeco-Latin square.
Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules.
In contrast to other Vitrocell® exposure modules, installation of QCMs at specific positions on the cultivation base module is not possible with the Vitrocell® 24/48 system.
The Vitrocell exposure modules dock under the dilution bar and smoke is drawn through the module onto the QCM (or cell cultures) via a vacuum; smoke not sampled through the module exhausts from the dilution bar (Figure 1).
This has also been noted by other users of linear exposure modules (such as the CULTEX module) where a large variation in response was observed as a certain limitation of the module's linear arrangement, thus a concentration gradient should be taken into consideration [16].
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