Further development of a concept of determinants of population exposure is needed, along with research to better identify these determinants.
This has limited the use of such technology in pre-clinical research where prolonged and constant exposure is needed to validate targets with less-than-ideal tool compounds to enable a data driven decision without significant upfront investment.
If it turns out that more general 'background' exposure is needed, e.g. organisms with low invasiveness or virulence, such as the rapid growing saprophytic strains of Mycobacteria, the idea of 'right' and 'wrong' types of microbial exposure is academic, unless we could engineer the 'right' exposure, without introducing dangerous organisms.
Continued research on the neurotoxic effects associated with low level developmental exposure is needed.
With higher temperatures, a shorter exposure is needed to cause injury (Lundskog 1972, Berman et al. 1984).
But indices of individual DBP exposure are needed," says Zhang, a scientist with Alberta Health and Wellness, a division of the Canadian provincial government.
Clearly, further research is needed, with better characterized exposure models, to explore this association in more detail.
However, post-approval trials with extensive patient exposure are needed to generate knowledge of more patient-specific clinical effectiveness and long-term safety, in particular with respect to rare adverse reactions.
It is, therefore, very unlikely that increased access (diagnostic bias) could explain the increased incidence in the non-White groups, although of course there may be other confounding factors, and studies with individual-level exposure are needed to address this.
Research is needed with more precise measures of exposure and on the health effects of concurrent exposure to multiple pesticides.
