ProjectRun21 will be the first study to prospectively include running experience and running pace as primary exposures for development of RRI while following a specific running schedule for half-marathon.
In the exposure range from 6 to 15 ppm, the time-to-tumor appearance decreased with increasing exposure concentration (Monticello et al. 1996), i.e. lower concentrations require longer exposures for development of tumors.
Another time interval of study exposure interest was the first 2 years of life, when infants/toddlers spend substantial amounts of time in the home; this may be a critical exposure window for development of allergy and asthma.
Cumulative exposure, however, might be more relevant than recent exposure for the development of PD.
In previous studies, exposure for fetal development was usually averaged over the longer third-trimester window.
An additional consideration is that the peripubertal period is likely not the only critical window of exposure for pubertal development.
A series of trypanocidal compounds were identified with suitable in vitro DMPK properties, including CNS exposure for further development.
Chronic diseases such as lung cancer require decades from initial exposure for the development of lung tumors.
However, we believe that prenatal exposure is likely to be more influential than postnatal exposure for the development of the central nervous system.
We further hypothesized that the combination of genetic predisposition, low income, and a living environment that is less conducive to physical activity constitutes a particularly high-risk exposure for the development of diabetes among recent immigrants (18, 19).
