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This disparity could be due in part to the use of different air pollution exposure estimation methods.
A summary of the relative performance of the different exposure estimation methods is presented in Table 1.
For OC, silicon and sulfur, roadside monitors were included in the calculations for all three of the exposure estimation methods.
Table 4 shows estimates of effects of PM2.5 and PM2.5 components on CIMT by the several exposure estimation methods and analysis models.
The method was selected after comparison with two other exposure estimation methods in a study conducted in seven European countries (Peters et al., 2011).
HRs were also stronger in the Nurses Health Studyy, which used the same exposure estimation methods and geographic area as the current study, although the women generally showed worse health indicators (e.g., less physically active, more current smokers) and lived in areas of lower socioeconomic status (Puett et al. 2008, 2009).
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The application of a distance-decay model [ 17] in the exposure estimation method M2 produced the worst predictions: only the correlation with proximity to all batteries within 50 km was positive and statistically different from zero: r = 0.21 (MSE = 0.28).
The associations were reasonably robust to exposure estimation method (nearest monitor, IDW and city-wide mean) and to adjustment for additional potential risk factors and other PM2.5 components, but not to control for metropolitan area.
For example, if 20% of workers are exposed to an occupational hazard that produces a real increase in the risk of lung cancer of 50%, a nondifferential misclassification arising from an exposure estimation method with sensitivity and specificity both equal to 80% will reduce the observable increase in lung cancer risk to about 20%.
Although estimating equations do not appear to have been previously applied to non-steady-state biomarker based exposure estimation, the method is quite flexible and appears to be reliable in this setting.
To refine the quality of exposure estimation, various spatiotemporal methods have been developed worldwide.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com