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This study examines the impact of partial distractor valence and schematicity (i.e., their relation to fear representation) on exposure efficacy.
The pharmacodynamic effects of CC-930 on select blood biomarkers associated with IPF were used to assess the relationships among the CC-930 dose, exposure, efficacy, and biologic activity.
Data on exposure, efficacy and toxicity were summarised using MS Excel spreadsheets.
These findings in turn raised questions about factors involved in human susceptibility, risks of pesticide exposure, efficacy of mosquito control, the value of sentinel animals in surveillance, and the roles played by various species in virus transmission and amplification.
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Exposure-efficacy models.
doses of TAK-875, (ii) characterize the exposure-efficacy response of TAK-875, (iii) identify the sources of variability associated with PK and efficacy parameters of TAK-875, and (iv) project HbA1c response with TAK-875 up to 24 weeks.
Applying a model-based meta-analysis approach, projected HbA1c response with TAK-875 at the selected therapeutic dose of 50 mg was consistent with that based on the exposure-efficacy response analysis.
The World Health Organization has recommended that advertising of unhealthy food to children decrease in quantity (exposure) and efficacy (power).
The corresponding cyclohexylalanine derivatives such as 25 afforded improved PK exposure and efficacy in a murine OGTT experiment.
The use of a classical pharmacodynamic model demonstrated a clear relationship between exposure and efficacy and enabled us to define the critical plasma or faecal ivermectin concentrations delimiting an exposure window associated with partial anthelmintic efficacy.
The once weekly, 30 mg/kg dose of ELN 457946 was anticipated to provide appropriate exposure and efficacy throughout the study.
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