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However, despite having high in vitro potency, the utility of DCU to investigate sEH is limited based both on its short t1/2 in rats [13 15] and its low aqueous solubility, which makes oral delivery of DCU to maintain prolonged and constant exposure difficult.
Information regarding the number of commercial sex partners in the last 12 months was missing for a substantial fraction of respondents making the assessment of exposure difficult.
This high variability makes the prediction of glycidamide exposure based on acrylamide exposure difficult, and it creates the need for measuring glycidamide exposure as well as acrylamide exposure.
This bolus exposure may have masked the effects of the earlier background exposure and would make assessing the effects of TCDD exposure difficult.
Each study had different cut offs for each quantile, which makes a true comparison of ALA intake exposure difficult since some studies had higher levels of ALA in their highest intake quantile than others.
He also points out that although one mining community had high mercury vapor exposure alongside high malaria prevalence, others had low mercury exposure and little malaria; that makes the effects of malaria and mercury exposure difficult to tease out epidemiologically from this one study.
Similar(49)
Further, some chemicals have short half-lives that make linking disease phenotypes to specific exposures difficult, yet these transient chemicals can have significant and lasting biological effects.
We considered developing a measure of total activity in the present study, reflecting both occupational and non-occupational exposures, but the variation in the length of the time frame for the last job reported in relation to our non-occupational exposures made logical combinations of the two exposures difficult.
Exact profiles of PCB exposure were difficult to determine, since PCB transfer from breast feeding was not recorded.
Tracking of exposure is difficult based on participation on multiple teams and variability in organizational rules.
In school we have more autonomy, which brings exposure to difficult situations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com