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For PFOS, the total exposure derived from the data of the EFSA [15] is significantly higher than the result obtained using the data from Fromme et al. [38].
In this study, we evaluated the relationship between SAB and traffic exposure derived from the residence of each participant.
It is a biomarker of fetal MeHg exposure derived from the benchmark dose analysis relating neurodevelopmental performance to the measured concentration of total Hg in cord blood (NRC 2000).
However, we acknowledge that we have employed high in vitro concentrations to achieve these effects, and it is unclear how such observations relate to the anticipated exposure derived from the inhalation of ambient air pollution.
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We calculated Kappa values comparing the categorised cumulative exposures derived from the first expert interview with the corresponding exposure categories derived from the retest.
For baseline nutritional exposures derived from the FFQ (total carbohydrate and leucine), models were additionally adjusted for total calories.
Average air pollution exposures derived from the CALINE4 model for each pregnancy period and during the entire pregnancy were similar and moderately to strongly correlated (Table 2).
Our finding that effect estimates for exposures derived from the 24-month back extrapolated model were intermediate between associations with exposures based on the nonextrapolated model and the 12-month extrapolated model supports this hypothesis.
First, the exposure derived from data covering the period 13 15 years is not measuring hazardous alcohol use but simply indicating medium to high levels in terms of the proportion of adolescents by age that are drinking on a weekly basis or typically consuming more than 3 units when drinking neither of which per se would classify the young person as drinking hazardously.
The CPA data are based on lifetime exposure derived from questionnaires that the parents of these 11- to 12-year-old children completed at home [ American Thoracic Society, European Respiratory Society (ATS/ERS) 2005] and is thus subject to their understanding and interpreting the question, as well as to recall bias.
Collectively, these data suggest a non-additive genotype-specific interaction between SSB consumption and SLC2A9 genotype, and imply a physiological mechanism whereby high simple sugar exposure derived from soft drinks over-rides the positive versus negative risk discrimination of the SLC2A9 gout risk alleles by interfering with the ability of SLC2A9 to transport uric acid.
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