This pattern was similar using other exposure cut offs for 12 and 52 weeks.
Exposure levels were cut off at 68 dB(A) for road traffic which was the highest exposure level in PHSurvey08.
Using a 26 week exposure cut-off, the number of exposed events 4002 in 350 years in 16, 591 patients suggests an annual incidence of around 11.4 for 16, 591 patients or 689 per million per year, using THIN data.
The data shown suggests that most of the cases occur within the first 12 weeks of statin exposure, although a 26 week exposure cut-off will allow less misclassification of exposed and unexposed cases.
The costs calculations utilized an updated estimate of €200817,3633 per IQ point decrement, with three hypothetical exposure cut-off points (hair-Hg of 0.58, 1.0, and 2.5 μg/g).
We also applied the same cut-off points as Roberts et al. for the number of previous and recent traumatic event exposure (cut-off points were eight and four events, respectively) and hence treated exposure to traumatic event as a dichotomized variable.
The small reduction in risk we observed when the respirable elemental carbon limit was set at ≤260 µg/m is mostly due to the limited person time above exposure cut-off, i.e., the intervention would have left the majority of the cohort unaffected.
A narrower exposure cut-off (75 m) was defined by Mc Connell et al. [ 18] in Southern Californian schoolchildren (aged 5-7 yearsignificantcassociationsions were found for lifetime asthma (OR = 1.29 95% CI 1.01-1.86), current asthma (OR = 1.50 95% CI 1.16-1.95) and wheezes (OR = 1.40 95% CI 1.09-1.78).
The pooled relative risk across all studies that used an exposure cut-off level set at 40 g alcohol per day or above, or defined exposure as a clinical diagnosis of an alcohol use disorder, was 3.50 (95% CI: 2.01 5.93).
Obviously, as churches go through these social media enriched transitions, each person will need to decide how much he/she needs to be cut off from "exposure" to the activities of the departing pastor or the congregation.
Therefore myopathy events were classified as "exposed" if they occurred within 12 weeks of new/change of statin and "non-exposed" if not on statin at time of myopathy event (or had been taking statin for greater than cut off for exposure time).
