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Exposure biomarker methods.
We identified exposure-source information for all 102 of the rodent mammary carcinogens and exposure biomarker methods for 73.
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About half of these pesticides have had some type of exposure biomarker method reported in the literature (e.g., Coronado et al. 2011; Riederer et al. 2008).
Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the "early-life exposome".
Exposure sources and biomarker methods for these are summarized in Supplemental Material, Table S1, along with methods for the chemicals in the groups described above.
This example also emphasizes that biomonitoring for chemicals that are widely used in consumer and personal care products (e.g., phthalates, BPA, parabens) requires additional considerations beyond choosing optimal exposure biomarkers and analytical methods.
Further, this methodology provides estimates of long-term exposure, which cannot be obtained from existing biomarker methods.
Sensitive and specific exposure biomarkers are one method to assess chemical exposures.
Because of the unequal distribution of characteristics among sites, we first used nonparametric methods to examine variation of exposure biomarker concentrations in relation to study characteristics.
The limitations of non-targeted metabolomics in dietary exposure biomarker discovery platforms arise from metabolite concentrations that can vary across cultivars, and inconsistencies in extraction methods or instrument detection limits.
Toward Capturing the Exposome: Exposure Biomarker Variability and Coexposure Patterns in the Shared Environment.
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