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Major segments of a somatosensory neuron (that is the cell body, axonal stem, peripheral and most of the central branches of the fibre) are located outside the blood-brain barrier and, thus, are exposed to circulation at least to some extent.
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To be specific, FRs-α is present in normal cells also but is not exposed to blood circulation whereas it is highly exposed to blood circulation in case of cancer cells making it as an attractive target for folate-conjugated nanoparticles which might be internalized via endocytosis mechanisms [18, 19].
Bioavailability is an important parameter, referring to the extent at which active agents are exposed to the circulation, which determines the amount of drug available to a target organ or site.
Thus in the norm the antigens of gut commensal microbiota are not exposed to systemic circulation.
Four distinct lineages of the outbreak VDPV circulated for up to two years (26 52 "generations") before transmission was terminated, and were present in all districts in Madura among subgroups of the population who were poorly immunised, had not been exposed to WPV circulation for over a decade and who lived in conditions conducive to poliovirus spread.
The ARC and VMH are exposed to the circulation owing to active transport of metabolic signals such as leptin, glucose and insulin across the blood-brain barrier.
Many experimental models have utilised either in vitro studies of isolated cell lines or animal and human studies where LPS is exposed to the circulation by parenteral injection.
The brain is rich in tissue factor, which is exposed to the circulation in large quantities when the blood-brain barrier is disrupted by trauma.
After an eye surgery or other trauma to the lens capsule, these lens antigens are exposed to the circulation, they may be recognized as 'foreign' by the individual's immune system and they incite an inflammatory response.
FR-α is a glycosyl phosphatidyl inositol (GPI -linked protein which is present in the apical reGPI -linkedmal cells which is not exproteino the blood circulation, whichas is case of cancer cells, it is expresento the blood cinculathen apicaleregion, fofate-conormaled nanoparticellsinternalized whichhish affinoty (rexposed-mediatod endocytheis) [24, 25].
Improved cutaneous healing in diabetic mice exposed to healthy peripheral circulation.
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