Exact(6)
However, when only the cases (n = 39) that were diagnosed more than six years after the baseline examination and their controls were studied, the women in the highest exposed quartile showed an increased risk to develop type 2 diabetes (OR of 1.6 [95% 0.61, 4.0] for CB-153 and 5.5 [95% CI 1.2, 25] for p,p'-DDE).
Analysis by quartiles of the population, with cases and controls taken together, revealed an OR value of 1.86, with 95% CI: 1.11 – 3.13 in the most exposed quartile.
The positive association between DDE exposure and T4 in the highest exposed quartile of girls is not in line with what has been reported in other observational studies [ 16, 28, 29], which either report no association or an inverse association.
The relatively long tails at both ends of the exposure range, may furthermore have contributed to the absence of an exposure-response relation in this study: the range of exposure within the highest exposed quartile for NO2 (16.5-36.0 μg/m) was much larger than the interquartile range.
This OR value is almost the same as that related to the most exposed quartile calculated on a population of 172 cases and 405 controls, which includes the 25 subjects (4 cases and 21 controls) not resident at 01.01.1960 but who moved to the Province of Venice before 01.01.1970: OR = 1.91, 95% CI: 1.14 – 3.1.14
Further, Meeker et al. (2010a) found a significant positive association with FSH and an inverse association with inhibin B. We observed a similar pattern in the present study, but only among men in the highest exposed quartile, and the associations in the present study were not statistically significant (p = 0.16 for FSH and p = 0.27 for inhibin B).
Similar(54)
We initially found a difference in unadjusted mortality rates according to the maximum age of red cells to which a patient had been exposed: the quartiles with older red cells were associated with a clear increase in mortality when compared with the lowest RBC quartile.
The estimated difference in mean birth weight among children in the highest acrylamide-exposed quartile compared with children in the lowest quartile was around 100 g, consistent with the reduction in birth weight observed for children exposed in utero to maternal smoking (Li et al. 1993).
Compared with children in the first quartile of exposure (least exposed), children in fourth quartile (most exposed) had rate ratios of 1.25 (p < 0.001) and 1.40 (p < 0.001) for AOM and LRTIs, respectively.
Mothers exposed to the highest quartile of the DWTD compared with those less exposed exhibited approximately 50% increased risk (adjusted odds ratio = 1.47; 95% confidence interval, 0.67 3.19).
Additionally, a higher relative risk of increased leptin secretion in both male and female infants corresponding to pregnant women exposed to the highest quartile BPA level.
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