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Although it was not practically possible to measure exposure to the full suite of chemicals to which these children are exposed, OPs as a class are among the most toxic chemicals in use by the agriculture industry and, as a class, present significant health risks.
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Families of OP users were included as subjects because they may have been exposed to OPs by washing clothes contaminated by OPs and/or by touching OP users.
Participants The subjects in the exposed group must either use OPs occupationally, or there must be a probability of being exposed to OPs during their work.
To elucidate early steps in the mechanisms of OP toxicity, we studied alterations in global gene and protein expression in Caenorhabditis elegans exposed to OPs using microarrays and mass spectrometry.
We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls.
We examined 230 subjects including 115 workers occupationally exposed to OPs and an equal number of normal healthy controls.
Present study was designed to determine the influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to OPs.
In conclusion, the results show that null deletion of GSTM1 and homozygote wild GSTP1 genotype could be related to inter-individual differences in DNA damage arises from the gene environment interactions in workers occupationally exposed to OPs.
The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs.
The results of this study suggest that GSTM1 null genotypes, and an association of NAT2 slow acetylation genotypes with CYP2C9*3/*3 or GSTM1 null genotypes may modulate DNA damage in workers occupationally exposed to OPs.
Exposure Participants must be exposed to OPs for at least 1 month.
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