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It was a hollow victory for the company; the long-running trial had exposed damaging stories about its business and the quality of the food it was selling to millions of customers around the world.
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This increase could be explained by the abolishment of chromosome end-to-end fusions that temporarily leads to higher number of exposed damaged telomeres as compared to cells proficient in the C-NHEJ (see Fig. 6).
Such evidence might well, if exposed, damage the agencies' reputation.
Since DNA is continuously exposed to damaging agents, and damaged DNA can derail the DNA replication machinery; a cell must either repair or bypass (via a process called translesion synthesis) this damage to copy its genome.
This indicates that cPAF might impair a proper DNA damage response if cells are exposed to damaging agents.
In low earth orbit (LEO), components of space systems are exposed to damaging hypothermal atomic oxygen and thermal fatigue.
Living cells are continually exposed to damaging ROS arising from normal cellular metabolism or from one-electron oxidations of xenobiotics.
Since DNA is continuously exposed to damaging agents, however, the problem arises as to how to transmit undamaged chromosomal DNA to the progeny.
Adult stem cells are slowly dividing, long-lived cells, which by their very nature are exposed to damaging agents for long periods.
As the colonic mucosa is permanently exposed to damaging mechanical and chemical stress factors, the maintenance of a proper organ function requires rapid renewal and differentiation of mucosal cells.
Our studies demonstrate that both Bax and Bid translocate from the cytoplasm to mitochondria during the early stages of excitotoxic cell death and that tBid also associates with Bax in OPCs exposed to damaging concentrations of glutamate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com