Filament formation is thought to occur by the interaction of the charged residues (exposed by coiled coil formation) between two dimers.
Finally, protein feature prediction methods such as those integrated into PredictProtein provide position-based annotations such as secondary structure states, buried and exposed residues, coiled-coil stretches, and disordered regions.
In the more complex test phase II, the coil was exposed to ITER TF coil relevant mechanical stresses in the winding pack and case.
Domestic water heaters that use solar radiation to heat water in coils exposed to the sun on a glass-covered black metal plate (flat-plate solar collectors) are found in areas where there is ample sunshine and relatively high energy costs.
Moreover, since the absolute improvements were quite balanced among the different types of mutations (ranging from 0.10 to 0.12), EASE-AA yielded higher relative improvements for mutation types which appeared to be more difficult to predict for all of the four compared methods (coils, exposed residues, and 'small' stability changes).
Other mAbs bound specifically the 5HB construct but did not compete with any of the mAbs tested, thus indicating that the complete HR-1 coiled coil region exposed in 5HB harbors antibody epitopes available for B cell recognition in the gp41 pre-hairpin conformation [65], [66].
The C-terminal ends of all the six peptides form helices or coiled coils, always exposed outside (Additional file 7: Figure S4).
It seems that the most difficult mutations to predict are either located in coil and exposed residues or those which cause only small stability changes (within the range of −1 and 1 kcal mol − 1).
If required, unscrew the inside-back of the freezer and expose the cooling coils.
Surrounded by 10-foot berms are three long, exposed holding pens, ringed by coils of concertina wire and visible only from a looming guard tower.
