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Thus, the cavities around exposed backbone hydrogen bonds are too small to enable penetration of a g = 3 water molecule.
Rugged protein structures maintain their integrity by promoting dehydration of exposed backbone groups aptly named dehydrons [4], [6].
For the side chains, the areas are divided by the surface area of the fully exposed side chain to determine the number of each type of side chain exposed; the total backbone surface area exposed is divided by a fully exposed glycine backbone for the number of exposed backbone units.
A special kind of structural deficiency, the exposed backbone hydrogen bond (EBHB) is identified in soluble proteins with PDB-reported structure [4], [6], [18].
For proteins with exposed backbone, the seal is shown to be maintained through a tightly fine-tuned distribution of sub-nanoscale curvatures of the protein enveloping surface that befits the low resilience of interfacial water in regards to retaining its coordination number (g = 3).
Similar(55)
Intrinsically disordered proteins (IDPs) are characterized by highly flexible solvent exposed backbones and can sample many different conformations.
The court heard that it was only a "miracle of surgery" that kept the victim alive after he was cut from the top of his neck to the bottom of his back, exposing his backbone.
This work explores the real possibility of water-tight protein structures that nevertheless expose the backbone, a paradoxical situation since structural integrity of soluble proteins requires the sealing of backbone hydrogen bonds.
With a band of sheer chiffon exposing the backbone or edging down the length of a garment, all at once the clothing becomes intriguing.
Our analysis is that this fit is driven, at least in part, by the need to exclude water from solvent-exposed backbone hydrogen bonds.
Once its backbone was exposed, the acylphosphatase started to form fibrils.
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