Assembly of this RNP governs the balance for nuclear export of different types of HIV transcripts, which is essential for promoting HIV infectious cycle.
Especially in differentiated cells with a high content of very dense heterochromatin but still active gene expression, clogging the paths to the NPCs should variably affect the export of different cargo molecules.
In this study, we show that XPO-1 inhibition using SINE compounds: KPT-185, KPT-205, KPT-225, and KPT-127 reduced, in a panel of PCa cells, XPO-1-dependent nuclear export of different proteins including AR, Foxo3a, and survivin, modulating cell cycle progression through both a G1 and a G2/M-arrest followed by apoptosis.
Open image in new window Fig. 2 Concentration of exports for different levels of aggregation, 2015.
See the Figs. 4, 5 and Tables 8, 9. Open image in new window Fig. 4 Concentration of exports for different levels of aggregation, 1997.
To assess the strength of the nuclear export activity of different fragments of Atx3 protein, or of full-length Atx3, the Rev(1.4 -GFP nuclear export assay, described previously by Henderson and Eleftheriou [42], was used.
This transport receptor helps to export hundreds of different proteins from the nucleus by recognizing a part of their structure called the 'nuclear export signal'.
An approach has been developed based on the mass balance of the pollutant to determine the export coefficients of different land use types (Ding et al., 2010).
With these mixed results, it is necessary to join this discussion and extend the boundaries of the literature with an international dimension, e.g. incorporating exporting and the diversification of exports to different country destinations.
This plasma membrane-localized transporter mediates export of many different organic anions including oligomycin as well as phospholipids [ 78- 80].
