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Using structural and functional conservation analysis of yeast and Drosophila mRNA export factors, we expose the evolutionary divergence of eukaryotic mRNA export pathways.
While mRNA export has been studied in yeast, the complexity of gene structure and cellular function in metazoan cells has likely led to increased diversification of these organisms' export pathways.
These existing import and export pathways could potentially be the pathways for substrate delivery to the IMS ribonuclease activity.
Alternatively, gag itself may be responsible for sorting cores into microvesicle export pathways [20], [38].
These different domain architectures suggest the presence of multiple export pathways in malaria parasites.
Characterization of these export pathways may facilitate the identification of novel drug or vaccine targets.
Different domain architectures of plasmodial exported proteins suggest multiple export pathways in malaria parasites [24].
Two genes of the sec independent twin arginine export pathways, namely TatC (Hore_03800) and TatA/E (Hore_03820) were identified.
Two antigens (aconitase and ATP synthetase) are mitochondrial proteins and 2 (BiP and TIP47) proteins of export pathways.
At this time, we can only speculate as to how RNA export pathways affect the membrane targeting function of HIV-1 MA.
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Flvcr1a fl/fl ;alb-cre mice that were unable to induce Flvcr1a, showed a stronger induction of the heme degradation and iron storage/export pathways, as an attempt to compensate for the lack of heme export.
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