Exact(5)
XPOT and XPO1 function in export of tRNAs and proteins containing leucine-rich nuclear export signals respectively.
Notably, balance between the import and export of tRNAs across the NE is determined by the physiological conditions.
While the majority of eEF1A1 associates with the cytoplasmic cytoskeleton and translational machinery (Ejiri, 2002), eEF1A1 is able to enter the nucleus to mediate the export of tRNAs and SNAG-containing proteins under normal growth conditions (Bohnsack et al., 2002; Calado et al., 2002; Mingot et al., 2013).
The export of tRNAs has been well studied.
Although nuclear export of tRNAs has been well documented, the import machinery is poorly understood.
Similar(54)
These include actin bundling, nuclear export of aa-tRNAs, proteolysis of misfolded proteins, modulating apoptosis, response to amino acid starvation and viral replication [ 9, 10].
Metazoan XPO5 representatives are responsible for export of eukaryotic elongation factor 1A (eEF1A), tRNAs [50], 60S ribosomal subunits [51] and short miRNA precursors [52][53].
The best studied of these new small RNAs are fragments of tRNAs that correspond to half of a mature tRNA.
This is not the case as the number of tRNAs present in OtV5 does not correspond to the most abundant tRNAs in the host (Wilcoxon test, P = 0.32).
Some snoRNAs control methylation of tRNAs [ 22, 23].
For example, when the dataset was constructed, part of tRNAs without typical cloverleaf structure were filtered.
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