It plays a central role in the synthesis and export of proteins and glycoproteins and is best studied in the secretory cells specialized in these functions.
Hematozoans, in particular, appear to have evolved novel systems for export of proteins into the host organelles and cell membrane during intracellular development.
CRM1/Exportin1 mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES) by forming a cooperative ternary complex with the NES-bearing substrate and the small GTPase Ran.
In Gram-negative bacteria Type II secretion system (T2SS) is one of six protein secretion machineries that permit the export of proteins from within the bacterial cell to the extra-cellular milieu and/or into target host cells.
CRM-1 is a protein required for the nuclear export of proteins containing an NES [27].
In summary, we have characterized diverse signals for the export of proteins by P. berghei.
Numerous lines of evidence have revealed the existence of a multi-component folding quality control system that regulates the export of proteins out of the bacterial cytoplasm [20].
In eukaryotic cells, nuclear export of proteins is frequently mediated by this nuclear export factor, which binds to nuclear export signals (NES) on cargo molecules.
