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Instead, this domain appears to mediate protein:protein interactions that facilitate the nuclear export of mRNA.
Nuclear export of mRNA, previously thought to happen exclusively through nuclear pore complexes, may also occur via a membrane-budding mechanism.
The inhibition of transmethylation reactions mostly affects the efficiency of gene expression, from the methylation of the promoters, cap formation, the stability and export of mRNA, to the initiation of translation.
Transcription and export of mRNA was upregulated.
Nxf1 is a gene that is involven in the export of mRNA from nucleolus to cytoplasm.
CF Im has a key role in APA and in the export of mRNA from the nucleus.
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While initial single-molecule studies focused primarily on import pathways using permeabilized cells, it has recently proven feasible to investigate the export of mRNAs in living cells.
Since eEF1A1 interacts with TPR1 during heat shock and is required for TPR1 binding to HSP70 mRNA and export of HSP70 mRNA from the nucleus, the transport mechanism appears to rely on eEF1A1-mediated activation of HSF1 and formation of the ternary complex of TPR1-HSF1-eEF1A1 TPR1-HSF1-eEF1A1 TPR1-HSF1-eEF1A1
Recent evidence has indicated that this complex would exert a post transcriptional enhancing effect, influencing export efficiency of mRNA to the cytosol and promoting transcriptional elongation and translation.
In eukaryotes, it confers stability for nuclear mRNA, regulates export of processed mRNAs to the cytoplasm and promotes translation initiation [1]; [2].
On mRNAs, the poly(A) tail protects the mRNA molecule from enzymatic degradation in the cytoplasm and aids in transcription termination, export of the mRNA from the nucleus, and translation.
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