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Human ABC transporters such as P-gp and MRP1 contribute to chemotherapy resistance, but small modifications to anthracycline compounds produce compounds such as annamycin with reduced export, leading to substantially improved activity against multidrug-resistant cancer cells [59].
Peatland drainage is extensive and increases aerobic decomposition and DOC export leading to a loss of ecosystem services such as sequestration and storage of C and the potential development of greenhouse gas hotspots [8, 26, 27].
These nuclear quality control systems prevent the function of the aberrant mRNA by triggering nuclear degradation or by nuclear export leading to cytoplasmic degradation.
Dopaminergic lesions result in the loss of DAT terminals through degeneration, but there are additional losses in DAT function that result from a simultaneous reduction of DAT export, leading to its accumulation in the ER Golgi compartment.
Further, our recent report shows that two digitalis-like compounds H-9 and ATE-i2-b4 induce JNK-mediated Nur77 nuclear export leading to β-catenin degradation and tumour growth inhibition (Sun et al, 2012).
When the nutrient intake exceeds expenditure, tissues such as the adipose, liver, and skeletal become saturated with lipids and result in an increase in lipid export leading to elevated plasma free fatty acids (FFAs) (Kahn et al., 2006, Fabbrini et al., 2010).
Similar(54)
The group single-handedly accounts for a fifth of South Korea's exports, leading many here to half-jokingly call their country the Republic of Samsung.
The concept has been exported, leading, for example, to the geodesic domes of American visionary Buckminster Fuller, potentially vast structures with which he hoped to rehouse humanity.
After the 2001 recession ended, imports rose even faster than exports, leading to a rapid rise in the American trade deficit.
Until recently, the government worried that allowing the currency to rise would let in more imports and stifle exports, leading to deflation.
The rising Japanese currency risks choking off exports, leading to the continuation of a period slow growth and weak inflation that stretches back a quarter of a century.
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CEO of Professional Science Editing for Scientists @ prosciediting.com