Whereas N-terminal phosphorylation is important for stabilization, C-terminal acetylation regulates the DNA binding properties of p53 by interfering with its nuclear import-export, degradation and tetramerization [8].
In addition, p53C275, 277A, which harbors mutations that disrupt heme binding, was found to be resistant to hemin-induced nuclear export and degradation, suggesting that the p53-heme interaction is required for heme-triggered p53 nuclear export and cytosolic degradation.
The tumor suppressor p53 interacts with p300 by two different regions, one located in the N-terminus and required for nuclear export and degradation, and the other near the C-terminal region, proximal to but different from the C/H3 region, which is required for activation of transcription [14], [17].
Gene transcription in eukaryotes is a complex process that starts with the recruitment of an RNA polymerase (RNA pol) complex to the gene promoter and is followed by a set of successive steps, such as initiation, elongation, splicing, termination, mRNA export, and degradation.
Modification of these two targets leads to their nuclear export and degradation in the cytoplasm.
Murine double minute 2 (MDM2) plays an important role in p53 nuclear export and degradation.
Several of these enzymes are involved in the synthesis, export, and degradation of glycoproteins.
Interestingly, insulin inactivates FOXO1 via Akt leading to its nuclear export and degradation.
AKT is known to suppress FOXO family by inducing phosphorylation, nuclear export, and degradation which lead to subsequent p21cip1 and/or p27kip1 reduction [ 40].
Our data indicate that BCL6 interacts with nuclear-translocated HB-EGF-CTF and that the nuclear export and degradation of BCL6 induces cyclin D2 upregulation.
