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However, in contrast to Ins7/9 and 15, pre-40S particles in Ins3, 5, 11, 13 and 17 were strongly retained in the nucleoplasm, which suggests that the mutations involved affect the export competence of these particles, either in cis or in trans.
These results indicated that the distinction between CUTs, SUTs, and mRNAs is made following transcription elongation but prior to the acquisition of export competence.
Recent studies confirmed that IGCs are involved in main steps of gene expression including association of active genes in specific "neighborhoods" [ 12– 14], and mRNA was shown to acquire the export competence in IGCs [ 15– 17].
As a consequence, the maturation of nuclear pre-60S particles is accompanied by major compositional changes that lead to a sequential reduction of complexity and to the acquisition of export competence.
Similar(54)
They are found in a diverse set of proteins that include the animal vitamin B12 uptake proteins transcobalamin and intrinsic factor, the bacterial polysaccharide export proteins, the competence DNA receptor ComEA, the cob(I alamin generating enzyme PduS and the Nqo1 subunit of the respiratory electron transport chain.
The release of these factors from pre-60S particles ensures their recycling and likely triggers conformational changes that are critical determinants for the progression of ribosome assembly, e.g. promoting export or subunit-joining competence.
The pre-60S acquires competence for nuclear export at the late nucleoplasmic stage and undergoes final maturation in the cytoplasm (Matsuo et al., 2014; Greber et al., 2015; Weis et al., 2015; Ma et al., 2017; Malyutin et al., 2017).
These findings suggest that rice PDIL1-1 helps retain proglutelin in the cisternal ER lumen until it attains competence for ER export [ 21].
Mr. Barroso said that Europe had sufficient competence in the area of export credits and that companies operating in that sector - some of which are state-controlled - could transfer their expertise and go into the business of rating debt.
A recent study by Deutsche Bank said China's technical competence in the equipment manufacturing sector was at a "golden stage" that would enable it to grab export market share from Japan, South Korea and Germany.
Competence matters.
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