In addition to exploring the target and antitarget lists of individual microRNAs, we also analyzed the merged target and antitarget lists for both the Dlk1/Gtl2 microRNAs and the randomly selected reference set.
A statistically significant effect of genotype was detected in the time spent exploring the target quadrant (Two-Way RM ANOVA, post hoc Holm-Sidak method, p < 0.05; Figure 6d).
In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells.
Luciferase reporter assay was used to explore the targets of two predicted novel miRNAs in this study.
To explore the targets directly regulated by miR-124, we used two algorithms that predict the mRNA targets of a miRNA-PicTar [29] and TargetScan [30].
44 However, further functional studies are still necessary to explore the targets and the exact role of these miRNAs in cancer cell biology.
We combined them into the set of upregulated miRNAs consisting of groups A and B and the set of downregulated miRNAs consisting of groups C, D, and E. We explored the targets for 171 miRNAs on the miRTarBase [ 26].
Further studies to explore the targets and the effects on their functions of anti-PC22 and anti-PEX.C22 (or anti-PAA9) would improve our understanding of the pathogenesis of NP-SLE.
A tetrazolium salt dye-based cellular assay was developed and qualified to define the cytotoxicity of virus preparations on susceptible cells and to explore the target cell specificity of PVS-RIPO.
