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We performed a sensitivity and meta-regression analysis, cumulating all randomized trials exploring the benefit of afatinib, erlotinib and gefitinib versus chemotherapy in advanced EGFR mutant NSCLC, to investigate the potential role of additional clinico-pathological predictors of TKIs efficacy.
Three studies exploring the benefit of combining gefitinib with the aromatase inhibitor anastrazole have been reported (Table 1).
Other studies are exploring the benefit of inhibiting downstream effectors such as p70S6 in combination with everolimus (NCT01115803).
A trial sponsored by the NCIC/CTG is currently exploring the benefit of adding TMZ to RT in patients aged >65 years.
A greater understanding of the biological mechanisms responsible for de novo and acquired endocrine resistance has led to the rational design of clinical trials exploring the benefit of combining hormonal therapies with novel biological agents in an effort to enhance the efficacy of ER+ breast cancer treatment.
Accordingly, an ongoing phase III, placebo-controlled trial led by Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) is exploring the benefit of 24 months of pazopanib monotherapy in the maintenance setting in patients with stage II IV ovarian disease without disease progression after first-line chemotherapy (AGOOVAR16; clinicaltrials.gov identifier NCT00866697).
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She asked him: "What happened to you?" As we continue exploring the benefits of mindfulness for work, scientists are researching the effects of the practices on the brain.
However, there is a paucity of literature exploring the benefits of social capital for sentenced prisoners.
This work focused on exploring the benefits of smart antennas and especially beamforming techniques in multipath fading ad hoc networks.
This finding provides the first empirical support for several qualitative studies exploring the benefits of participation in workplace team sport [10 13].
Several thousand titles on the Mills and Boon back list have been converted to ebooks, but the company is also exploring the benefits of social media.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com