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Bunescu and Mooney (2005) developed a machine learning approach that explores a sequence kernel measuring the similarity of two sentences by evaluating the common string sequences that they contain.
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The obtained library diversity explores a comparable sequence space as the donor-derived natural repertoire and, at the same time, is able to access novel recombined diversity due to lack of segmental linkage.
The methodology of MOTU definition, as implemented in jMOTU [ 51], explores a defined range of sequence divergence thresholds upon which a plateau of MOTU richness, i.e. potential barcoding gaps, can be identified.
In RNA inverse folding, we explore an RNA sequence space to find the RNA sequences that fold into a user-given target structure, where 'a sequence folds into a structure' means that the structure is the optimal structure (eg, the lowest free energy structure or the centroid structure) of the sequence.
In this study we explored a whole-genome sequencing approach using the Illumina HiSeq 2000 platform to identify insertion points and possible genomic rearrangements in four selected plasmid insertion mutants with reduced virulence to wheat.
This method not only provided a simple, economical and reliable fluorescent NAD+ assay but also explored a flexible G-rich sequence regulated NCB probe for the fluorescent biosensors.
Furthermore, they explore a greater amount of sequence information because they have higher throughput and lower costs than other methods.
Deflection sequences explored a spatial region defined as a grid of discrete positions (Materials and Methods; an example "diamond" grid used in the simulations is shown under the polar plots in Fig. 2).
A more complex algorithm that explores sequence space by clustering similar sequences with up to 3 nt substitutions has also been used previously, and our results would support this type of approach [ 15].
We explored a total of 14 498 726 EST sequences from the dbEST database (NCBI) in 257 plant genera from the IUCN Red List.
The structure of clustering was explored by fitting a sequence of finite mixture models to the means of posterior distribution of FST values for each locus.
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