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Dihydrofolate reductase (DHFR), which catalyzes the last step, is one of the most thoroughly explored targets of this pathway, but there are no DHFR inhibitors used for tuberculosis treatment.
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Previously, Part 1 and Part 2 of this series explored targeting arbitration-eligible and pre-arbitration-eligible outfielders, respectively.
During the past decade, a number of investigators have thus explored targeted strategies involving autoantigens in order to subvert or block key steps of the disease.
We explored target genes of individual miRNA by using the Diana-microT 3.0 target prediction program, and selected the genes with the miTG score ≧ 20 as the set of highly reliable targets.
Mallouk et al. have recently reported the ultrasound-driven propulsion of nanowire motors in living cells, while Nelson et al. have explored targeted drug delivery based on magnetically propelled artificial flagella.
Here we discuss existing drugs that inhibit organellar translation, and explore targets that may be further exploited in antiparasitic drug design.
In this study, we applied Cytoscape to explore targets expression data in the context of biological network information.
11 16 This in turn has enabled us to explore targets such as the '18 weeks' target that involve a longer part of the patient journey through a number of clinics within the obesity system.
Ongoing analysis is focusing on the I-SPY 1 patients who did not have a complete response to therapy and had early recurrence, using the described biomarkers as well as phosphoprotein profiles, to explore targets for future therapeutic intervention.
As publishers explore targeted advertising on Google and other search engines or social networking sites, they figure that a digital cover remains the best way to represent a book.
In addition, Kabam aims to produce a greater assortment of original and branded social games and explore targeted acquisitions similar to its purchase of WonderHill in October 2010.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com