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Explored objects may contact multiple digits simultaneously so information about motion must be integrated across digits, a process about which little is known.
These results suggest that during a single test trial the mice were able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered, and (c) to discriminate the relative recency in which different objects were presented.
The participants' task was to indicate whether the haptically explored objects possessed the "same shape" or had "different shapes".
Twenty-four hours later, the mouse was returned to the arena containing one of the previously explored objects and a novel object.
Chan, Whitaker, and Newell (2008) investigated the effect of object presentation in a task where participants haptically explored objects that consisted of specific pairs of shape and motion.
In a recent study exploring somatosensory discrimination by fMRI we were able to show that the right prefrontal cortex is involved during the phase when retrieval of information from episodic memory is critical for the comparison of sequentially explored objects [ 44].
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Forty-eight hours later, object recognition memory was tested using a previously explored object and a novel object.
Eight months old mice displayed good memory of a previously explored object, indicated by higher preference for a new versus the old object (Fig. 6c).
After this run, one of the objects was replaced with a novel object, and the third run was in the arena with this novel object and the previously explored object.
Novel object discrimination requires the subject to discriminate between a previously explored object and a novel object.
In the ORT, mice spent more time exploring a novel object than a previously explored object if the memory of the familiar object was still intact [ 53, 54].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com