Sentence examples for explored in models of from inspiring English sources

Our data indicates that C-2 has higher TPx and Antioxidant activity and importantly, C2 did not induce toxicity even when tested at relatively high doses, indicating that its pharmacological properties should be further explored in models of diseases associated with oxidative stress.

Antiapoptotic agents have been successfully explored in models of diseases affecting the central nervous system, liver and kidneys [ 55- 57].

The therapeutic potential of Evasin-3 was explored in models of heart ischemia reperfusion in the mouse (Montecucco et al, 2010).

Finally, in a post-hoc manner, the 8 independent variables described above were explored in models in which total number of surgeries, frequency of surgery in a one year period and time between last and second last surgery were modeled as continuous variables.

Consequently, the effects of myostatin inhibitors are being explored in animal models of inherited and acquired neuromuscular disorders and of age-related loss of muscle mass.

To date, the functional consequences of B7-H1 inhavetion have been extensively explored in other models of virus-induced demyelination, such as infection with the JHMV strain of mouse hepatitis virus (MHV) [17].

Some researches on combinations of several growth factors have been explored in animal models of coronary artery disease and peripheral arterial disease.

Although these mechanisms have yet to be explored in animal models of PD, given that gliosis and inflammation are increasingly recognized as features of PD pathology (Whitton, 2007), it is very likely that some component derived from activation of astroglial group III mGlu receptors contributes to the overall protective potential of targeting these receptors in PD.

To overcome the toxicity of systemic delivery, direct ex vivo transduction of tumor cells with cytokine-encoding complementary DNAs has been explored in mouse models of mammary carcinoma [ 25, 26].

The interaction between α-syn and DJ-1 has been explored in cellular models of α-syn overexpression, suggesting that DJ-1 is involved in preventing α-syn toxicity by induction of HSP70 (GenBank NM_005345) [33].

Isoenzyme-selective inhibitors have also been explored in animal models of COPD in an effort to overcome side effects.