Sentence examples for explored in mice from inspiring English sources
Pulmonary delivery of soluble antigen arrays (SAgAs) was explored in mice with experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model.
In this work, sesquiterpenoids from the root of Panax Ginseng (SPG) were prepared, and then the hepatoprotective effects of SPG against CCl4-induced acute liver injury were investigated and the underlying mechanism was explored in mice.
Whether these interactions can profitably be explored in mice remains an open question.
The function of H19 has been explored in mice and cell lines by using knockdown and transgenic approaches.
Importantly, the physiological role of the polyQ-repeated expansion in higher organisms has been recently explored in mice carrying only seven CAG repeats within the murine Htt gene.
The possibility of using interleukin 2 (IL-2 -activated IL-2 -activatedcells (A-NK) to carry methoxymorpholIL-2 -activatednatural; PNU 152243) to liver-infiltrating tumours was explored in mice bearing 2-day established M5076 reticulum cell sarcoma hepatic metastases.
Like many other assumptions, this hormonal or endocrine hypothesis was primarily explored in mouse, although human genome and physiology significantly diverge from the rodent settings.
Moreover, the known interaction of Notch with the presenilin proteins suggests a juncture in the disease pathways underlying VCI and AD, which also could be further explored in mouse models.
To overcome the toxicity of systemic delivery, direct ex vivo transduction of tumor cells with cytokine-encoding complementary DNAs has been explored in mouse models of mammary carcinoma [ 25, 26].
The function of ETS fusions in cancer has been further explored in mouse models where ERG expression results in the development of PIN only in the context of the phosphoinositide-3-kinase (PI3K) pathway activation (King et al, 2009), and combination with other lesions such as AR overexpression or PTEN loss leads to invasive adenocarcinoma (Carver et al, 2009).
The complex process of thymocyte selection is difficult to explore in mice with a polyclonal T-cell repertoire and is more readily dissected by working with thymi that express a TCR complex with known specificity and hence a fixed repertoire.
