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Finally, issues of design modification are explored for further reduction in the start-up time.
The mechanism of catalysis by hybrid microgels was explored for further development in this area.
Hydrazinocurcumin (HZC) is a patented multiactivity compound and is a potent derivative of curcumin which is not yet explored for further development as formulation and requires the determination of biopharmaceutical suitability of the molecule.
Using the docking model of compound 1 bound to PKCθ as a model, structure-based drug design was employed and two regions were identified that could be explored for further optimization, i.e., (a) a hydrophilic region around Thr442, unique to PKC family, in the inner part of the hinge region, and (b) a lipophilic region at the forefront of the ethyl moiety.
The data provided are not complete to dissect the sequences and cellular functions required for late replication of subtelomere segments, but provide useful data that can be explored for further studies.
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Additional analyses were done to explore for further evidence of an intervention effect.
Thus, the study identified a mean of 2,333 +/-328 (SD) peptides per patient sample corresponding to 307 +/-16 proteins and a total of 344 proteins in all CSF samples analyzed by LC-MS (Additional file 3: Table S2), a rich resource to explore for further biomarker definition and insight into the CNS disease pathways.
In the present study, weight advantage of liquid hydrogen as an ideal fuel has been explored for its further utilization in such aircraft.
This approach could be further explored for clinical studies [105].
These compounds will be further explored for structure activity relationship.
In this direction, electrospinning has been further explored for the generation of ceramic nanofibre.
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