Suggestions(2)
Exact(3)
We next explored whether changes in CV risk factors (explored as continuous variables, with change standardized to the IQR of each variable) influenced PWV over time (Table 3).
All these three determinants were initially explored as continuous variables and subsequently categorised as binary variables (using the median value as cut-off) for illustration of the results.
The EIs were explored as continuous variables [daily values, weekly sums, and 28-day total (∑EI) for each woman] and as quantiles (dichotomized at the median).
Similar(57)
When NW was explored as a continuous variable, the increased odds of hypertension associated with a unit change in NW were almost perfectly null: 1.005 (95% CI 0.997 - 1.014).
Similarly as in previous analyses, ferritin was explored as a continuous variable with a natural logarithm transformation and dichotomous variable (with the third quintile ferritin selected as the cutoff: ≤47.2 or >47.2 ng/ml).
Antibody concentrations were initially explored as a continuous variable, then categorised into 'positive' (>12 U/ml), 'equivocal' (8 12 U/ml) and 'negative' (>8 U/ml) categories based on standard laboratory thresholds.
In the sensitivity analysis, cardio-protective medication was explored as a continuous variable and results did not differ; this suggests that collapsing medication change into an ordered categorical variable did not obscure a small change.
Distance to highway was explored as a continuous variable, but was found to not be appropriate since there is a gap between 450 m and 1000 m where participants were intentionally not recruited as part of the CAFEH study in order to maximize exposure contrast in the study population.
Continuous variables (maternal age, BMI) were explored both as continuous and categorical variables, to ensure that this did not have an important effect on any of the multiple logistic regression models.
In medical research, continuous biomarkers have been commonly explored as diagnostic tools to distinguish subjects, such as diseased and non-diseased groups [ 1].
Novel, integrated hPSC bioprocesses, whereby multiple unit operations are carried out using continuous culture strategies, are being explored as an alternative to segregated bioprocess strategies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com