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"This is very, very interesting," says Mien-Chie Hung of the University of Texas MD Anderson Cancer Center in Houston, who is exploring treating tumors with nanoparticles.
One avenue being explored is treating for a period of time and then stopping in hopes of stimulating the immune system to combat H.I.V.
Based on our data, such analogs might be worth exploring in treating T2DM.
Exon skipping has also been explored for treating mdx heart disease.
Therefore, determining how remyelination occurs in white matter under pathologic conditions may identify new therapeutic avenues to explore to treat CNS disease.
The role of both proteins was therefore explored by treating MCF-7 cells with fulvestrant, an antagonist of ERα, or with pifitrin-α, an inhibitor of p53.
Since aurora kinases play an essential role in cell division (Vader & Lens, 2008), we explored whether treating melanoma cells with an aurora kinase inhibitor would result in aberrant mitosis.
However, after it was demonstrated both in rats with induced systemic arthritis and in rats with an experimental allergic encephalomyelitis (a model for multiple sclerosis) that autologous BMTs were potentially equally effective as allogeneic transplants, this modality has been widely explored for treating refractory AD of all sorts.
Although accumulating evidence supports a working mechanism through voltage-gated sodium (Nav) channels, we found that a clinically relevant rufinamide concentration inhibits human (h Nav1.1 activation, a distinct working mechanism among anticonvulsants and a feature worth exploring for treating a growing number of debilitating disorders involving hNav1.1.
Because anomalous hNav1.1 behavior has been implicated in LGS, the therapeutic effects of rufinamide may indeed stem from its ability to shift the voltage dependence of activation of hNav1.1 channels to more positive potentials, a notion worth exploring for treating disorders involving hNav1.1 gain-of-function mutations such as GEFS+, migraine, and post-traumatic stress disorder.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com