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To explore the sequence of deformation and the underlying failure mechanisms, a combined experimental/numerical study was carried out.
We use flexible backbone protein design to explore the sequence and structure neighborhoods of naturally occurring proteins.
We sought to explore the sequence basis of substrate differences using a phylogeny-based design of site-directed mutations.
In this paper, a neural network-based algorithm is proposed to explore the sequence of the measured point data for surface fitting.
This design allowed us to explore the sequence requirements to functional adaptation of each loop replacement that may not be sampled otherwise.
Comparative sequence analysis was used to explore the sequence space of the RA motif within ribosomal RNAs in order to define its canonical sequence space signature.
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The aim of this study was two-fold: firstly, to explore the sequence-dependent cytotoxic effects of combining ZD1839 with radiation using a panel of six human head and neck squamous cell carcinoma cell lines; and secondly, to investigate the sequence-dependent cytotoxic effects of combining ZD1839 with cisplatin and/or 5-FU on two of the cell lines from the panel.
Urlinger, S. et al. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity.
Exploring the sequence space of enzyme catalysts is ultimately a numbers game.
Utilizing various modalities of the Rosetta Molecular Modeling Software Suite including flexible peptide docking and protein design, we comprehensively explored the sequence space recognized by the CCT domain.
As a foundation, the ML framework is built for two categories of iterative optimization techniques (i.e. deterministic and stochastic) capable of exploring the sequence alignment space.
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