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When the photographers' fifteen minutes were up, I was escorted out and sent to explore the arena.
Mice were placed in the center of the apparatus and allowed to freely explore the arena.
A rat is gently placed into the corner of the field, and allowed to explore the arena for 30 minutes.
The animal was placed in the outer part of the arena facing an outer wall and allowed to freely explore the arena for 5 minutes.
Colonies housed in their old nest were positioned in the middle of the central dish (Figure 1) and allowed freely to explore the arena.
The rat was allowed to explore the arena for 30 minutes after which they were subcutaneously (sc) injected with either ketamine (2.5 and 5 mg/kg), MK-801 (0.08 and 0.16 mg/kg), or vehicle (0.9% NaCl) and returned to the arena for a further 90 minutes.
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Once released, individual flies explored the arena using a series of straight flight intervals punctuated by saccades (Fig. 1a).
Normal behavior of rats consists of moving around and exploring the arena, including doing rears to investigate the surroundings.
Participants explored the arena for 2 3 min using right-handed button presses to move forward, left, and right.
This response was distinct to that seen in animals that explored the arena in the dark in the absence of spatially configured odor cues (Supplementary Fig. 4).
The results in Table 1 showed that adult control females displayed higher exploration than males when challenged to explore a novel environment; control females spent more time exploring the arena and showed more returns between OF and home cage, and when in the OF arena, they spent more time in the bright zone and in the central area of relative to males.
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