To explore the alterations in cardiac excitation-contraction coupling, cardiomyocytes from APP/PS1 and WT mice were exposed to norepinephrine (NE, 1 µM) and isoproterenol (ISO, 0.1 and 1 µM) and myocyte shortening was examined.
To further explore the alterations in glucose homeostasis associated with OSA in NGM, we compared HOMA estimates and insulin levels in the subjects with NGM stratified by OSA severity.
Therefore, exploring the alterations in task-related DMN deactivation and functional connectivity that affect episodic memory in T2DM will help to enhance our understanding of the allocation patterns underlying memory function in T2DM.
Funded by the National Institute of Mental Health, scientists in the Conte Center are pioneers in the diverse fields of brain plasticity, connectomics, genomic imprinting, and super-resolution imaging, exploring the alterations in neural circuits that underlie disorders such as autism, schizophrenia, anxiety, and depression.
Metabolomics is a powerful tool for exploring the alterations in the metabolite abundance, and metabolic pathways and networks which are involved in various pathophysiological conditions and offers the platform for identification of genotype-phenotype as well as genotype-envirotype interactions (Kumar et al., 2014).
In the second example, we propose to explore the alteration of synaptic transmission in a model scenario for Autism Spectrum Disorders, which was recently shown to be associated to a mutation in the Shank3 scaffolding protein, a fundamental molecule of the PSD interacting with PSD 95.
In collaboration with Dr. Qi-Min Zhan at Chinese Academy of Medical Sciences and Peking Union Medical College, whole-genome sequencing, exome sequencing, and array comparative genomic hybridization analysis were recently used to explore the genomic alterations in esophageal squamous cell cancer (ESCC) [8], one of the most aggressive cancers and the 6th leading cause of cancer death worldwide [9].
Since these factors are considered important for proliferation and differentiation, we also explored the possible alterations in their expression in gastrointestinal neoplasias.
In this study we explored the genomic alterations in NB from the data generated by A-CGH on a cDNA microarray platform.
We also developed a SNP array data analysis approach to discriminate CCN alterations from amplification bias artifacts, which will be useful for exploring the chromosomal alterations in single cells.
