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Philip Glass and Robert Wilson first brought "Einstein" to the surface in 1976, after exploratory trials in Europe, with two performances at the Metropolitan Opera House.
The British drug research and development company Amarin said yesterday that exploratory trials of the drug Miraxion showed results "significantly superior" to a placebo in treating depression that does not respond to existing drugs like Paxil or Prozac.
Very early in the discovery of new drugs, Phase 0 studies (exploratory trials) are sometimes performed before proceeding to a Phase 1 study.
In addition, we review previously published findings from the completed phase I safety and phase II exploratory trials.
This chapter details the basic characteristics of such trials and shows the opportunities elicited by smart designs of exploratory trials, exploratory investigational new drug (eIND) filing, microdosing studies, early decision making, adaptive trial design, and the combination of regulatory and exploratory trials.
The working group focused on defining exploratory trials on medicinal products and developing recommendations for their implementation in France (notably concerning non-clinical requirements, the pharmaceutical quality of the investigational medical product and the conditions under which this type of clinical trial may be performed).
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Data were collected as part of an observational study nested within a broader exploratory trial of Healthy Mind.
The results of this exploratory trial show that culturally adapted psychoeducation was an acceptable and feasible intervention in a low-resource setting.
A conventional power calculation was inappropriate for this exploratory trial.
The second paper addresses phase 2, the exploratory trial.
Fifty eight patients were recruited to the exploratory trial.
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