The rationale for this exploratory investigation was to compare immunological responses to the recombinant methylated HBHA produced in Mycobacterium smegmatis [9], methylated synthetic peptides from HBHA, Purified Protein Derivative (PPD), and the proteins with the documented high specificity for M. tuberculosis infection ie. ESAT-6 and Culture Filtrate Protein Derivative (CFP-10).
The data presented in this exploratory study thus provide the rationale for future studies with a controlled design to confirm the effects on lipid profiles and MIF levels in relation to cardiovascular endpoints.
The rationale of the present exploratory data analysis was to divide the task into phases characterized by their specific sensorimotor and cognitive aspects.
All studies should acknowledge the number of analyses or brain correlations performed, giving a clear rationale for each, to avoid conducting exploratory analyses and reporting the most significant result; viii.
Most resources advise caution in interpreting these investigations, noting their exploratory nature, but when there is a clearly stated rationale, especially when derived from previous research, and sufficient trials are included, a priori planned investigations may improve applicability.
If the planned sample size is not derived statistically, then this should be explicitly stated along with a rationale for the intended sample size (eg, exploratory nature of pilot studies; pragmatic considerations for trials in rare diseases).
More phase II exploratory trials are thus needed to firmly establish a sound rationale.
Although there is a biological rationale to support the present observations, the present data are exploratory and retrospective.
From this perspective, the origin, context and pedagogical rationale of the curriculum are described including the discussion of an exploratory study based on discourse analysis and how it has informed our pedagogical practice.
The rationale for adopting grounded theory was its ability to guide the exploratory nature of the study and allow emergence of theory from the data [ 41].
