These conclusions from small-animal models were further substantiated in exploratory proof-of-concept studies in dogs [17] and pigs [22] with protective positive PEEP ventilation.
While such predictive capability must remain a major longer-term scientific goal, the scope of the Environment and Human Health programme in its first phase has been of necessity more pragmatic, with a focus on exploratory ("proof-of-concept") research and building the interdisciplinary community required for the task.
This study was designed as an exploratory, hypothesis generating, proof-of-concept study.
While these exploratory studies demonstrate their proof of concept, each involved administration of single mini-tablets, whereas multiple mini-tablets are more likely to be used clinically to provide the appropriate dose.
We performed a single-site, proof-of-principle exploratory study of menthol PKs following a single 187 mg oral dose of PMO (Colpermin capsule; Tillotts Pharma, Rheinfelden, Switzerland).
The primary objective of this prospective, proof-of-principle exploratory study in patients with metastatic and inoperable pancreatic cancer was to examine the feasibility of CTC enumeration across this heterogeneous patient population, comparing the CellSearch and ISET platforms, in order to determine the utility of CTCs as a source of biomarkers in this disease setting.
Altogether, these points show that the analysis approach presented here is mostly useful for exploratory analysis and offers only limited statistical proof for any of the findings.
When Rackspace launched their private cloud offering, they saw a lot of nibbles from organizations doing proofs-of-concept and other exploratory actions.
We have also illustrated the validity and utility of the DiCE strategy using four case studies: two proof of principle examples and two exploratory examples.
An exploratory randomised controlled trial was conducted to test proof of concept of RESTORE: a web-based tool to enhance self-efficacy to manage cancer-related fatigue.
