Sentence examples for exploratory pathway from inspiring English sources

In exploratory pathway analyses we did not observe an association between TLR-NFκB related genes and breast cancer risk.

Subsequent exploratory pathway analyses using the GRASS algorithm found no associations for genes in TLR or NFκB pathways.

As an exploratory pathway analysis, we used the GRASS algorithm to examine genes in the KEGG "Toll-like receptor signaling pathway".

Exploratory pathway analyses of rank-ordered genes revealed the modulation of Nrf2 or Nrf2-mediated oxidative response after 3 months of fish oil supplementation (P = 0.01) [ 112].

The gene set ridge regression in association studies (GRASS) algorithm was used to conduct exploratory pathway analyses for genes in TLR or NFκB pathways [ 35].

Similar to the analysis of the disease-associated genes, an exploratory pathway analysis using IPA was completed for the 61 genes closest to the CpG probes most associated with OS (meta-analysis p < 0.01).

However, the information regarding the connections between pathways through molecular interactions and reactions are not included and adequately represented to support the exploratory analysis in most pathway mapping tools (reviewed in Gehlenborg et al., 2010), for example, GenMAPP (Salomonis et al., 2007), Pathway Explorer (Mlecnik et al., 2005) and Pathway Projector (Kono et al., 2009).

At this time, patients with drug-resistant HER2+ breast cancer are a subgroup of intense focus in exploratory trials with PI3K pathway inhibitors.

In addition, in silico pathway-based exploratory analysis predicted that these differentially expressed circulating miRNAs might affect critical pathways conducive to breast cancer formation and progression, a potentially important mechanism warranting further investigations.

Our global exploratory approach identified biological pathways modulated along with PIP expression, providing further support for its good prognostic value of disease-free survival in breast cancer.

To further explore the potential roles of these circulating miRNAs in breast carcinogenesis, we applied pathway-based bioinformatics exploratory analysis and predicted a number of significantly enriched pathways which are predicted to be regulated by these circulating miRNAs, most of which are involved in critical cell functions, cancer development and progression.