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10 Secondarily, using follow-up outcome data from similar studies, an exploratory estimation was made to determine likely cost-effectiveness based on cost per QALY gained.
As it stands, my default inclination is to think of the exploratory estimation methods as being "feature extractions" in pattern recognition (i.e. a data dimension reduction step).
Safety was assessed by adverse events (AEs), vital signs, and laboratory evaluations, as defined in e-Appendix 1. Post hoc exploratory estimation of myocardial oxygen consumption (MVO2) was carried out as defined in e-Appendix 1.
However, while theoretical considerations are developing, this study provides a first exploratory estimation of a SEM for coverage decision-making as well as measurement models that can be used for further analysis.
Even though we are well aware that the virtual lack of fossils impede a precise calibration of the molecular clock in red algae, we used divergence rates already published for plants and red algae as an exploratory estimation of the historical events of divergence that have occurred in M. laminarioides.
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To distinguish between exploratory period estimation and BWB based on a particular period estimation technique, we will refer to the use of period estimation methods within BWB as embedded.
The integer period discrete Fourier transform (IPDFT) is a variant of the well-known discrete Fourier transform (DFT) that is tailored for the integer-period problem of exploratory period estimation, however the two are virtually equivalent for the purposes of confirmatory period estimation.
Note that these distributions are not periodicity profiles typical of exploratory period estimation applied to a single sequence fragment, but the aggregation of dominant period counts derived from exploratory period estimation over many sequence fragments.
Exploratory period estimation seeks to discover the existence of dominant periodic components in a sequence.
Our comments concerning the use of exploratory period estimation for confirmatory purposes have been revised to clarify their meaning.
The Hybrid autocorrelation-IPDFT combines the strengths of the autocorrelation and DFT methods for exploratory period estimation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com