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The Albumin in Acute Stroke Part 1 Trial: an exploratory efficacy analysis.
Exploratory efficacy measurements included WHO functional class and parent's and clinician's Global Clinical Impression scales.
The exploratory efficacy determination will be a composite of cardiovascular death, myocardial infarction, ischemic stroke, and stent thrombosis.
To assess the safety, pharmacokinetics, and exploratory efficacy of SM04690, a novel Wnt pathway inhibitor, as a potential disease modifying treatment for knee osteoarthritis (OA).
Exploratory efficacy measures included reduction in frequency of moderate or severe headache days.
Both of these factors may have contributed to an overestimation of the effect of CC-930 on disease progression and exploratory efficacy parameters.
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As an exploratory analysis efficacy against severe malaria was also assessed in this cohort, with an estimate of 57.7% (16.2 80.6; p = 0.019).
The aim of the PIFI study is to build on the lessons learned from the exploratory FIFI efficacy study and to design, deliver and evaluate three interventions of differing intensity and duration targeted at couples but channelled through the male partner.
The Bayesian sample size proposed by (Whitehead et al., 2008 [27]) for exploratory studies on efficacy justifies the acceptable minimum sample size by a "conclusiveness" condition.
Numerous exploratory safety and efficacy end points were assessed and, as such, had no prespecified primary end point, and the study was not powered to conclusively evaluate its objectives.
Exploratory endpoints include efficacy in tumours with GNAQ or GNA11 mutations.
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