Sentence examples for exploratory drug from inspiring English sources

Positive performance of an exploratory drug in experimental xenografts of different human cancer cell lines is not predictive enough of compound efficacy in the clinical setting [ 32].

Following these concepts in April 2004, US FDA published a draft guidance regulating early human screening studies, and in January 2006 new industry guidelines for early exploratory drug studies in humans have been issued (http://www.fda.gov/cder/guidance/7086fnl.htm).htm

Response assessment by imaging is now intimately involved with all stages of the drug development process, from exploratory drug discovery through clinical trials, as well as in clinical use.

It is important to understand the potential of a new chemical entity to have significant pharmacokinetic (PK) interactions with commonly administered comedications as early in the exploratory drug development process as possible.

The dose-dependent effects of the exploratory drugs are shown in Fig. 1 and statistical analysis is reported in Supplementary Fig. S1.

Exploratory drugs were diluted at the desired concentration directly in physiological 0.9% NaCl saline for oral administration of a volume close to 1 ml.

In this study, low concentrations of fenugreek extract was found to induce death of Jurkat cells, a commonly used cell line model to understand anticancer functions and underlying mechanisms of exploratory drugs or compounds.

These include exploratory research, drug discovery initiatives, biopharmaceutical production, target validation, and high-throughput screening.

The use of adaptive study design in early exploratory clinical drug development, if thoroughly planned, is beneficial as it allows continuous learning from data that is being gathered.

Using this exploratory approach, drugs appeared to modulate amygdala reactivity in only one smoker subgroup but not in either nonsmoker subgroup.

The different MIC value suggested that the activity of zolpidem is sensitive to the carbon source of the media, to the degree of aeration, and/or to the presence of bovine serum albumin, as is seen for other exploratory antitubercular drugs.